GPNMB and COVID-19: We calculated enrichment scores for both the Gpnmb RecAM gene signature and the fibrotic features gene signature in marker lists from published scRNA-Seq datasets from 2 distinct forms of human lung disease (COVID-19 and asthma), a mouse model of live Pneumocystis lung infection, and mouse macrophages isolated from skin wounds of healthy and diabetic mice (Supplemental Table 3) (24, 29, 52–54).