We calculated enrichment scores for both the Gpnmb RecAM gene signature and the fibrotic features gene signature in marker lists from published scRNA-Seq datasets from 2 distinct forms of human lung disease (COVID-19 and asthma), a mouse model of live Pneumocystis lung infection, and mouse macrophages isolated from skin wounds of healthy and diabetic mice (Supplemental Table 3) (24, 29, 52–54). Here, GPNMB is linked to lung disorder.