Unlike T‐cell IC, which directly depletes itself, B‐cell ICs primarily influence T‐cell function and secretion of immunosuppressive molecules, indirectly suppressing antitumor immunity.[49, 50, 85] Bregs with high expression of TIM‐1 not only secreted large amounts of IL‐10, but also inhibited the function of CD8+ T cells, thereby attenuating anti‐tumor immunity.[49] Similar effects were observed in Breg with high expression of PD‐1.[50] Furthermore, B‐cell ICs can significantly impact B‐cell function. The gene discussed is CD8A; the disease is neoplasm.