T cell ICs often hinders the cellular immune response in TME due to their functions in depleting T cells and limiting T cell cytotoxicity.[92, 94, 101] Activated B cells have been demonstrated to produce tumor‐specific antibodies that exert anti‐tumor effects.[6, 63] High expression of IC by B cells, such as TIM‐1, may limit B cell activation.[26] Thus, the presence of B cell IC signaling may have a detrimental effect on antibody production by B cells. The gene discussed is HAVCR1; the disease is neoplasm.