CD8A and neoplasm: T‐cell ICs primarily exhaust T‐cells and inhibit their cytotoxic effects in order to directly impede the antitumor immune response.[50, 93, 94, 101] For example, studies have demonstrated that tumor‐infiltrating CD8+ T cells with high TIGIT expression can limit the effector function of these cells.[101, 102] In a study analyzing specimens from pancreatic cancer patients, an increase in T‐cell TIGIT expression within the tumor was identified, which correlated with a T‐cell depletion phenotype.[94]