GCG and Insulin resistance: Injection of GLP-1 analog Exendin-4 (Ex-4) decreased the body weight (Figure 2G) and improved both glucose tolerance (Figure 2H) and insulin resistance (Figure 2I) in control and Piezo1 IntL-CKO mice, while endogenous synthesis of GLP-1 was not changed by Ex-4 injection in Piezo1 IntL-CKO mice (Figure 2J and K).