GLP1R and type 2 diabetes mellitus: Yoda1 treatment or intestinal bead implantation enhanced GLP-1 production and improved glucose metabolism in the diet-induced diabetic mouse model, suggesting that restoring the mechano-sensing or enhancing the function of Piezo1 either pharmacologically or mechanically, may be a new strategy to improve the secretion of GLP-1 and alleviate T2DM.