TOP1 and cancer: To assess the broad effectiveness of TCMCB07 treatment in chemotherapy-induced anorexia and weight loss, we generated 6 rat models of chemotherapy, representing commonly used classes of cancer chemotherapeutics: (a) cisplatin (platinum compound), (b) 5-FU (antimetabolite), (c) CP (alkylating agent), (d) vincristine (vinca alkaloid), (e) doxorubicin (anthracycline), and (f) a combination of irinotecan (DNA topoisomerase I inhibitor) and 5-FU.