ARSA and cardiac hypertrophy: Our multi-omics study highlights specific genes and pathways that are linked to these organ functionalities: cardiac hypertrophy (CACNG4, GJA5, THBS2, FBLN1), skeletal system development (ADD2, TRAM-1, NEAS), calcium signaling (CAMK2B, PDE8B), synaptogenesis (APOE, GABBR2, ARSA, BEX1), and STAT3 pathway (WNT16) (Fig. 2c).