CRK and myelodysplastic syndrome: Indeed, other MDS-locus genes are involved in various signaling and metabolic pathways (YWHAE: signal transduction pathways [22], CRK: signal transduction [23], PITPNA: Inositol lipid signaling [24], RPA1: DNA metabolism [25], METTL16: methionine cycle [26]) emphasizing the importance of studying gene deletions in MDS (Fig. 1a).