HAND2 and atrial fibrillation: At the RNA level, RT-qPCR confirmed expression changes in CACNG4 (cardiac arrythmia [48]), GJA5 (atrial fibrillation [49]), THBS2 (angiogenesis inhibitor [50]), ADD2 (membrane skeletal protein, synaptic plasticity [51]), and HAND2 (neurogenesis [52]) (Fig. 3a).