METTL16 and osteosarcoma: Because the expression level of METTL16 impacts global protein and SAM/SAH levels, we also wondered if METTL16 contributes to the cell migration defect because (i) it is a gene in the MDS locus (Fig. 1a) whose expression in MDS cells is 50% less than in non-MDS cells at both the RNA and protein levels (Fig. 1e and S5) and (ii) depletion of METTL16 in hepatocellular carcinoma, osteosarcoma, and colorectal cancer cell lines decreases cell proliferation, migration, and invasion [83, 100, 101].