The disruption of mTOR signaling by METTL16 may contribute to any MDS symptom but most especially severe neurological abnormalities [14] that cause intellectual disabilities, seizures, and epilepsy [15], congenital heart abnormalities (enhanced hypertrophy, ventricular septal defect) [16], gastrointestinal and/or kidney functionalities (multicystic dysplastic kidney), and motor coordination impairments [10]. Here, MTOR is linked to ventricular septal defect.