Similarly, another study of MDS patient-derived organoids established destabilized microtubule organization and impaired β-catenin activation in the N-cadherin/β-catenin signaling axis of MDS, reiterating the importance of PAFAH1B1 and YWHAE in diminished cell migration during cortical development [19]. Here, PAFAH1B1 is linked to myelodysplastic syndrome.