STAT3 and cardiac hypertrophy: While more genes were altered at the RNA level (~ 2800 differentially expressed genes (DEGs)) than the protein level (~ 450 DEGs), our multi-omics results and pathway analyses uncovered significantly enriched genes associated with key regulatory pathways, including synaptogenesis, cardiac hypertrophy signaling, STAT3 signaling, and EIF2 signaling, which may contribute to dysfunctions of the brain, heart, and other vital organs [27].