CAMK2B and myelodysplastic syndrome: Because our transcriptomics analysis identified elevated Ca2+ and cAMP-mediated signaling in MDS (Fig. 2c) and CAMK2B was 2.5-fold higher in MDS cells at the protein level (Fig. 3d), we performed a cAMP direct immunoassay, which indirectly measures the calcium levels via cAMP levels.