In addition, we discovered seven other potential key transcriptional regulators of gene expression networks in type 2 diabetes (ESM Fig. 2): Etv1, Irx1 and Foxp1 (alpha cells); Ehf, Hhex and Tcf4 (delta cells); and Zfhx3 (macrophages). This evidence concerns the gene TCF4 and type 2 diabetes mellitus.