N-terminal pro B-type natriuretic peptide (NT-proBNP) is a cleaved inactive peptide of B-type natriuretic peptide produced from the myocardium in response to cardiac ventricular stress, and has been shown to be a reliable biomarker for heart failure and other cardiovascular complications in individuals with or without diabetes [13, 14]. The gene discussed is NPPB; the disease is diabetes mellitus.