In a recent systematic review of novel biomarkers for predicting cardiovascular events conducted as part of the international consensus report on precision medicine in diabetes [7], a total of 218 studies, covering 195 unique biomarkers, were investigated, and it was concluded in the systematic review that NT-proBNP was one of the most promising biomarkers for prediction of cardiovascular risk in people with type 2 diabetes [3]. This evidence concerns the gene NPPB and diabetes mellitus.