Concerning the four grade 3 severe CTCAEs unrelated to TILs or Proleukin® (IL-2), nivolumab has the following characteristics: ‘alteration of general condition’, ‘basal cell carcinoma’, and ‘haemorrhagic stroke’ regressive with minimal sequelae such as psychomotor slowing and ‘infiltrating carcinoma of the right breast’. Here, IL2 is linked to medical procedure.