↑ heart weight (at d18.5)Altered cardiac expression of genes involved in metabolism (↑Pparg, Cd36 and Prkaa1) with predicted ↓ neoplasia and DNA repair/synthesis and ↑ lipid synthesis and metabolism in males, ↓ immune cells and ↑ uptake of mono- and polysaccharides in females. The gene discussed is PRKAA1; the disease is neoplasm.