Collectively, these findings reinforce the existence of two distinct groups of glycosyltransferases (FUT3, FUT4, FUT6, ST3GAL4 vs FUT7, FUT9, ST3GAL3, ST3GAL6) potentially responsibly by sLe antigens biosynthesis in CRC, suggesting patterns of co‐expression or regulatory relationships among them. The gene discussed is ST3GAL4; the disease is colorectal carcinoma.