Intestinal I/R injury post ischemia is related to the activation of the JAK2/STAT3 pathway and beclin-1-mediated autophagy inactivation, and AG490 inhibiting the JAK2/STAT3 pathway reactivates autophagy, enhancing survival after intestinal ischemia-reperfusion injury (Liu et al. 2022a, b). Here, STAT3 is linked to ischemia.