These results demonstrated that hepatic Pparg modulates TG homeostasis, contributing to hepatic steatosis, but protects other extrahepatic tissues (such as muscle) from TG accumulation and insulin resistance (Ahmadian et al., 2013; García-Ruiz et al., 2007; Gavrilova et al., 2003; Matsusue et al., 2003). The gene discussed is PPARG; the disease is fatty liver disease.