ACACA and fatty liver disease: In this work, we used HFD-induced obese mice to investigate the effects of clopidogrel on the initiation and progression of hepatic steatosis and its potential mechanisms and observed that clopidogrel ameliorates HFD-induced hepatic steatosis in obese mice by attenuation of aberrant fatty acid de novo biosynthesis via the multiple MASLD-associated pathways, or primarily through enhanced phosphorylation of the AMPK/ACC pathway.