We found learning and memory impairment and BBB disruption as well as reduced cerebral blood flow in the MOX + CP 673451 group, suggesting that amelioration of neurological dysfunction in the VD rats by moxibustion could act by affecting the GVU, and influencing the expression of pericyte PDGFRβ, which in turn regulates the expression of astrocytes and related gap junction proteins. This evidence concerns the gene PDGFRB and sexually transmitted disease.