FOXO3 and Alzheimer disease: This study failed to show any statistically significant differences in the prevalence of other ageing related genotypes, such as the ApoE4 genotype, FOXO3A rs2802292 (TT genotype) or PON1 rs662 (RR genotype) between Sardinians and other Italians or Ikarians and other Greeks.3 Other prevalence studies amongst Okinawans have shown that the ApoE4 genotype, which increases the risk for Alzheimer’s disease, has a higher frequency of .005 amongst supercentenarians of Okinawa compared to the Japanese control of .097.80