Moreover, it has been established that the AGE–RAGE pathway plays a prominent role in the development of fibrosis, including that of cardiac, renal, hepatic, and pulmonary tissues [27,28,29], and it has also been reported that AGEs are pathological factors involved in the occurrence and development of diabetic retinopathy and have accordingly been identified as therapeutic targets for blocking the progression of this disease [30]. The gene discussed is AGER; the disease is diabetic retinopathy.