In general, the overwhelming expression of Pim-3 precipitated by a low miR-936 level plays an active role in guiding the activation of the ANKRD18A/Src/NRF2 pathway, in which the expression of indicated proteins related to iron homeostasis and lipid peroxidation is rearranged to favor ferroptosis in liver cancer. This evidence concerns the gene ANKRD18A and liver cancer.