Accordingly, we hypothesized that aberrant expression of Pim-3 driven by a low miR-936 level activates the ANKRD18A/Src/NRF2 pathway to enhance the transcriptional activity of NRF2, thereby regulating iron homeostasis and lipid peroxidation and constraining sorafenib-induced ferroptosis in liver cancer cells. Here, ANKRD18A is linked to liver cancer.