For instance, the study conducted by Nguyen et al., observed that curcumin conjugated with anti-death receptor 5 (DR5) antibody by regulating the ROS and iNOS levels activated in HScs, and it additionally, suppressed the α-SMA expression in fibroblast suppressing the cancer-associated fibroblast activity in enhancing cancer progression (83). Here, TNFRSF10B is linked to cancer.