Repudi S et al. (2021) designed and produced an adenoassociated viral vector (AAV9) harbouring murine Wwox or human WWOX cDNA and driven by the human neuronal Synapsin I promoter (AAV-SynI-WWOX). Testing the efficacy of AAV-SynI-WWOX delivery in Wwox-null mice demonstrated that specific neuronal restoration of WWOX expression rescued brain hyperexcitability and seizures, hypoglycemia, myelination deficits, and the premature lethality and behavioural deficits of Wwox-null mice. This evidence concerns the gene WWOX and Hypoglycemia.