Isola et al. (2024) conducted a parallel-arm, randomised clinical trial on forty-two periodontitis patients to compare the outcome of minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels, and their association with clinical implications. Here, PLA2G7 is linked to periodontitis.