IMMT and adenoma: It has been speculated that this is due to a multistep progression from adenoma to carcinoma and that identifying early drivers in the initiation of tumorigenesis could lead to earlier detection and more targeted therapies, improving clinical outcome such as a positive outcome with positive lesional p87 expression in CRC [31], similar to that of pancreatic cancer [32,33] However, the order in which these drivers occur is not well established.