ERBB2 and cancer: However, in cases concerning rare cancers (such as angiosarcoma (28), metaplastic breast cancer (29)), high risk, relapsed or refractory pediatric cancers (such as Neuroblastoma (30), pediatric brain tumor (31), medulloblastoma, Wilms’ tumor (32, 33)), and resistant cancer sub-types (characterized by overexpression of HER2, Ras/MAPK pathways (34)), customized/personalized cell therapy, gene therapy, immunotherapy, and/or a combination of treatments in a timely manner can successfully aim to prolong symptom free survival in cancer patients (35–41).