In other words, NAIP/NLRC4 inflammasome-mediated pyroptosis eliminates the replicative niche for Salmonella. In addition, other studies have shown that GSDMD restricts Salmonella Typhimurium loads in the gut tissue and systemic organs, controls gut inflammation kinetics, and prevents epithelium disruption by 72 h of the infection (110). Here, NLRC4 is linked to infection.