The delayed pyroptosis of macrophages induced by the Salmonella plasmid virulence gene spvB was associated with the influence of the NLRP3 and NLRC4 inflammasomes, and spvB inhibited the production of ROS and the activation of NLRP3 at the early stage of infection, and subsequently inhibited the activation of NLRC4 (71, 72). The gene discussed is NLRP3; the disease is infection.