Soluble VISTA released by acute myeloid leukemia cells enhances the effects of Gal-9, most likely by forming multiprotein complexes on the T-cell surfaces and possibly creating a molecular barrier Gal-9, which results in changes in the plasma membrane potential of T cells; this leads to activation of granzyme B inside CTLs, followed by their apoptosis (59). Here, LGALS9 is linked to acute myeloid leukemia.