CD274 and systemic lupus erythematosus: In a murine SLE model, the application of anti-PD-L1 could alleviate proteinuria and prolong survival via the suppression of CD4+ T-cell activation, T helper 17 differentiation, autoantibody-containing immune complex deposition in the kidneys, and cytokine production (including that of IFN-γ, IL-17, and IL-10) (109).