Gal3BP, also known as tumor-associated antigen 90K or Mac-2-binding protein, is a multifunctional secreted glycoprotein encoded by LGAL3SBP involved in cell-cell and cell-matrix interactions, upregulated in patients with cancer or a viral infection, including HIV-1, HCV, or SARS-CoV-2 infection, with a key role in regulating the antiviral immune response (85). Here, LGALS3BP is linked to COVID-19.