LGALS3 and neuroblastoma: Interactions between Gal3BP and Gal-3 can trigger IL-6 expression and release in various cells, such as bone marrow stromal cells, neuroblastoma cells, and macrophages; this is because Gal3BP downregulation leads to decreased IL-6 expression, and Gal3BP/Gal-3-mediated induction of IL-6 involves the Ras-Mek-Erk1/2 pathway (85–88).