CDX2 and metastatic malignant neoplasm in the lymph nodes: Several factors have been identified as potentially influencing prognosis, including smoking history, Eastern Cooperative Oncology Group (ECOG) performance status, tumor size ≤ 5 cm, lymph node metastasis, and expressions of biomarkers such as CK20, CDX-2, and NapsinA (15, 34–37).