A recent publication from the CHIC Project Consortium (CHIC, 2017) describes a molecular model (as a plug-in component of a cancer digital twin) that combines the ErbB Receptor-Mediated Ras/Raf/MAPK and PI3K/AKT pathways (Chen et al., 2009) with p53-Mediated DNA damage-response module (Choi et al., 2012) by establishing interaction between the two models via the state of the common nodes, namely, Erk, Akt and PTEN (Kolokotroni et al., 2024). Here, TP53 is linked to cancer.