AKT1 and cancer: A recent publication from the CHIC Project Consortium (CHIC, 2017) describes a molecular model (as a plug-in component of a cancer digital twin) that combines the ErbB Receptor-Mediated Ras/Raf/MAPK and PI3K/AKT pathways (Chen et al., 2009) with p53-Mediated DNA damage-response module (Choi et al., 2012) by establishing interaction between the two models via the state of the common nodes, namely, Erk, Akt and PTEN (Kolokotroni et al., 2024).