Patients who have mutations in genes including TP53, BRCA1, BRCA2, CDH1, PALB2, ATM, or have an inherited syndrome such as Peutz-Jeghers syndrome, PTEN, Hamartoma tumor syndromes, Neurofibromatosis type 1 are at a higher risk of developing malignancy, so this cohort of patients may need an earlier qualification for biopsy or removal of the lesion (34). This evidence concerns the gene PALB2 and Peutz-Jeghers syndrome.