Given that M2-like TAMs are primarily associated with a tumor-promoting role in TME, we examined the distribution of genes associated with angiogenesis (VEGFA and PIGF (Jetten et al., 2014)) and myeloid-derived suppressor cells (MDSCs) recruitment to compare the tumor-promoting functions of three TAMs subclusters in the scRNA-seq data (Figures 2C, 3A, B). The gene discussed is PIGF; the disease is neoplasm.