Despite reduced VCAM1 and ICAM1 levels detected in the aortic arch, consistent with an atheroprotective phenotype, enhanced VCAM1 expression has been observed in the descending aorta of Jcad-knockout mice, indicating that Jcad could also have a site-specific effect in contributing to atherosclerosis (Douglas et al., 2020). Here, ICAM1 is linked to atherosclerosis.