Laminar flow enhances integrin α5β1–Gα13 coupling and represses YAP through decreased RhoA activity (Wang L. et al., 2016), whereas the disturbed flow enhances active nuclear YAP through the integrin α5β1 signaling path and c-Abl kinase (or ABL1) to boost downstream ICAM1 and VCAM1 expression and atherosclerosis (Li et al., 2019). This evidence concerns the gene ICAM1 and atherosclerosis.