Despite the comprehensive documentation of the phytochemical profile and composition of AR root extracts (Saran et al., 2020; Borse et al., 2021; Guo et al., 2022; Saggam et al., 2022; Prasad et al., 2024), the exploration of AR and its constituents’ potential in combating HIV-1 infection remains largely uncharted territory. Here, AR is linked to HIV-1 infection.