Although studies have indicated that multiple signaling pathways, including RNA interference (RNAi), the stimulator of interferon genes (STING) signaling pathway, and the NF-kB signaling pathway, are involved in the immune response of Bombyx mori to viral infections (Jiang, 2021), the immune mechanisms between Bombyx mori and BmNPV have not yet been effectively elucidated. Here, STING1 is linked to viral infectious disease.