,11,12,13,14,15,16 These studies identified proteins involved in multiple pathways, including inflammation (IL-6, TNF, IL-8, and CXCL6), immune cell activation (CD244 and CD40), coagulation (D-dimer, fibrinogen, and factor-D), apoptosis (TRAIL and SCF), and endothelial dysfunction (ACE2 and KRT-19). The gene discussed is CXCL8; the disease is endothelial dysfunction.