ITGAE and obesity due to melanocortin 4 receptor deficiency: It is known that obesity alters the transition of inflammatory cells through the airway epithelium to the lumen, modifying the expression of adhesion molecules such as the epithelial cell adhesion molecule (EpCAM) or the integrin CD103,4,31 which contributes to damage to the lung parenchyma through prolonged exposure to inflammatory factors secreted by these cells.