The paper highlights the complex overlap between hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) across different age groups. It emphasizes that while both conditions share common features like microangiopathic hemolytic anemia and thrombocytopenia, they differ in underlying mechanisms, such as complement dysregulation in HUS and ADAMTS13 deficiency in TTP. This evidence concerns the gene ADAMTS13 and congenital thrombotic thrombocytopenic purpura.