PLOD1 and central precocious puberty: Cases with CPP were divided into two groups: Group 1 during the lockdown period from April 2020 to April 2021, and Group 2- from 2017 to 2020. CPP was defined as breast development before 8 years of age and basal luteinizing hormone (LH) levels (LH >0.3 UI/L) and/or LH levels >5 IU/L on the GnRH-stimulated test.