Li et al. [38] previously demonstrated that isoliquiritin could improve neuronal survival and morphology, and reduce pyroptosis-related neuronal cell death by decreasing the levels of TNF-α, IL-1β, IL-6, cleaved Caspase-1, NLRP3, and GSDMD-N, thereby ameliorating depression. The gene discussed is NLRP3; the disease is depressive disorder.