IGFBP3 and sarcopenia: In addition to IGF-1, within the IGF family, we found that IGF-1R increased whole body fat-free mass, and IGFBP-3 and IGFBP-7 increased appendicular lean mass, and improved muscle mass and muscle bulk, demonstrating that high IGF-1R, IGFBP-3, and IGFBP-7 levels may reduce the risk of sarcopenia.