IGFBP3 and amyotrophic lateral sclerosis: However, conflicting findings exist regarding the clinical significance of IGFBP-3 in sarcopenia, as one study suggests that approximately 95% of circulating IGF-1 binds to IGFBP-3 and acid labile subunit (ALS) to form a ternary complex, hindering the translocation of IGF-1 into the intracellular compartment and consequently extending its serum half-life and regulating its availability (50).The data regarding the clinical role of IGFBP-3 in sarcopenia are characterized by inconsistency and contradiction.