The Wald ratio showed that elevated IGF-1R levels significantly improved whole body fat-free mass traits (OR=1.023, 95% CI=1.008-1.038, P =0.002), and IGFBP-3, IGFBP-7 were positively correlated with appendicular lean mass of the extremities (OR=1.034, 95% CI=1.024-1.044, P = 0.000; OR = 1.020, 95% CI=1.010-1.030, P = 0.000), improving muscle mass and reducing the risk of sarcopenia. This evidence concerns the gene IGFBP3 and sarcopenia.