Besides APOE, several other genes implicated in lipid metabolism, such as ATP-binding cassette subfamily A member 1 (ABCA1), ATP-binding cassette subfamily A member 7 (ABCA7), and phospholipase D3 (PLD3), have been associated with AD risk (7).The above shows the complexity of the pathological development process of AD. The gene discussed is ABCA7; the disease is Alzheimer disease.