Besides APOE, several other genes implicated in lipid metabolism, such as ATP-binding cassette subfamily A member 1 (ABCA1), ATP-binding cassette subfamily A member 7 (ABCA7), and phospholipase D3 (PLD3), have been associated with AD risk (7).The above shows the complexity of the pathological development process of AD. This evidence concerns the gene APOE and Alzheimer disease.