EGFR and central nervous system cancer: For example, dual-target CAR-T cells (e.g., targeting EGFR and IL-13Rα2 [150], targeting EGFRvIII and wide-type EGFR protein [215] ) and triple-target CAR-T cells (e.g., targeting EphA2, IL-13Rα2, and EGFRvIII [154]) have demonstrated promising potential in glioma therapy.