Specifically, EGFRvIII enhances the EGFRvIII-PI3K-AKT signaling pathway, the EGFRvIII-Ras-Raf-MEK-ERK/MAPK signaling pathway, and the EGFRvIII-JAK-STAT signaling pathway to promote the proliferation, survival, invasion, and angiogenic capabilities of GBM [86]. Here, SOAT1 is linked to glioblastoma.