ALPL and skeletal dysplasia: Although in Colombia, the genetic study is not mandatory to confirm and report the disease, the 18 patients had a genetic study performed by different methodologies (Sanger sequencing, NGS and qPCR of the ALPL gene and NGS panel for skeletal dysplasias), in which at least one variant in the ALPL gene was evidenced, most of them being autosomal recessive forms (Table 2).