S100B and neoplasm: Additionally, Collagen I intensity normalized to tumor surface area, as measured by the intensity of S100b positivity, was significantly increased by over 11‐fold in large VS compared to small tumors (mean fluorescence intensity normalized to cell count 16395 vs 1430, 1‐way ANOVA with Tukey's post hoc test, P = .0002) and to peripheral nerve control (1714, P = .0275) (Figure 3K).