Our results revealed several notable findings, including the following: (1) SMG-1 exhibited higher expression levels in HNSCC tissues than in normal tissues but had no significant effects on HNSCC tumor growth; (2) silencing ofSMG-1 sensitized HNSCC tissues to radiotherapy, and lower SMG-1 expression in HNSCC patients contributed to better survival time in patients receiving radiotherapy. Here, SMG1 is linked to neoplasm.