We recently identified an ecDNA species in the parental SNU16 gastric cancer cell line that contains no oncogene-coding sequences but, instead, originated from a non-coding genomic region between WDR11 and FGFR2. This region has accessible chromatin, is marked by histone H3 lysine 27 acetylation (H3K27ac) and contacts the FGFR2 promoter, suggesting the presence of active enhancers18 (Fig. 4a and Extended Data Fig. 9a). Here, FGFR2 is linked to gastric cancer.