Then, evaluating AKI patients according to CRS severity, we observed that while there were not significant differences in IL-6 elevation [peak IL-6 in CRS stage 3–4 patients 4575(4500) vs. 2939 (2239) ng/ml in CRS 1–2 patients, p = 0.6], patients developing AKI in concomitance of severe CRS stage 3–4 had a significantly high need of intensive care support [seven (100%) required ICU admission and six (85%) vasopressor support]. Here, IL6 is linked to congenital rubella syndrome.