IGF1 and ischemia: Owing to the unique and double features of a huge number of effective growth factors included in PRP such as hepatocyte growth factor (HGF), insulin-like growth factor-1 (IGF-1), and epidermal growth factor (EGF) that carry multifactorial features in tissue regeneration, repair of renal tubules, proliferation of endothelial cells, curbing tubular necrosis, and renal healing after ischemia.