Owing to the unique and double features of a huge number of effective growth factors included in PRP such as hepatocyte growth factor (HGF), insulin-like growth factor-1 (IGF-1), and epidermal growth factor (EGF) that carry multifactorial features in tissue regeneration, repair of renal tubules, proliferation of endothelial cells, curbing tubular necrosis, and renal healing after ischemia. Here, EGF is linked to ischemia.