Specifically, we targeted large genes PRKG1, NEGR1, and MAGI2 in fibroblast line UM-HF1 (HF1) and FHIT and WWOX in lymphoblastoid line GM12878 and colon cancer line HCT116 as model systems for replication stress-associated SV formation (Supplementary Fig. 1A and B). Here, NEGR1 is linked to malignant colon neoplasm.