Interestingly, immunohistochemistry shows that the levels of OGT and whole protein O-GlcNAcylation are upregulated in NEPC compared to adenocarcinoma, while OGT mRNA levels are not statistically different in NE-related groups versus control in NEPC datasets, suggesting the upregulation of OGT in NEPC is induced by enhanced protein stabilization rather than transcriptome alteration. This evidence concerns the gene OGT and adenocarcinoma.