The livers (Supplementary Fig. 4A), hind legs (Fig. 2O–R, Supplementary Fig. 4B, C) and mandibles (Supplementary Fig. 4D, E) of mice injected with PC-3-Thr163 PSA cells showed higher number of tumours, which also correlates with whole-body tumour load (Supplementary Fig. 4F) and serum PSA levels (Supplementary Fig. 4G) compared to those injected with Wt PSA or vector. Here, KLK3 is linked to neoplasm.