PROS1 and posterior cortical atrophy: The lower PSA levels among the C-allele rs17632542 variant men are more likely prone to: 1) a negative detection bias as fewer of these men would be referred to prostate biopsies and; 2) due to this PCa-detection bias, more likely to be diagnosed with more advanced disease stages as their referral for a biopsy would be delayed due to a more modest PSA elevation and a higher ratio of free-to-total PSA.