To evaluate the context-dependent effect of the rs17632542 SNP in the tumour microenvironment in bone and ability to induce invasive phenotype, the effects of the furin-activable PSA variants on bone metastasis in-vivo were investigated by intracardiac (left ventricular) injection of tumour cells for arterial blood dissemination (Fig. 2N). The gene discussed is KLK3; the disease is neoplasm.