Although this locus also colocalised with an eQTL for PRKD2 in transverse and sigmoid colon tissue (PP4 94%) and this locus is also associated with IBD risk, in keeping with our previous study7 our analysis supported a different causal variant driving the IBD and PSC associations in this region (PP3 for colocalisation of the PSC locus with UC and CD, 94% and 97% respectively). Here, PRKD2 is linked to inflammatory bowel disease.