Interestingly this differs from the previous candidate genes for this UC locus, SCAMP3 and MUC1. However, a role for GBAP1 in IBD is supported by the fact this same variant has been shown to increase expression of GBAP1 in a peripheral blood eQTL study of patients with CD, resistant to anti-TNF treatment58. This evidence concerns the gene SCAMP3 and inflammatory bowel disease.