Interestingly, with regards to the immune response genes, we observed a decrease of LYZ, GZMK, XCL1, CCL3, CXCR4, and an increase of CX3CR1, GZMH, GZMB, HAVCR2 (encoding TIM3) in the TME (Fig. 4c, d), indicating a switch of immune response features of NK cells during MM progression. The gene discussed is GZMB; the disease is Miyoshi myopathy.