Interestingly, we observed that two CD8 GZMB+ subsets, one CD4 GZMB+ subset and one γδ T GZMB+ subset was predominantly derived from individual patients and were detected at both time points (Fig. 6d), suggesting that GZMB+ cytotoxic T cells may perform anti-tumor specific immune response in the TME. Here, CD8A is linked to neoplasm.