While the Sugiyama model indicated that CYP2D6 had the highest degree of betweenness; both CYP2E1 and CYP3A5 trigger common diseases with CYP2D6. For comprehension purposes it is known that adverse drug reactions (ADRs), Drug Allergy, chemical and drug-induced liver injury, Parkinson’s disease, Schizophrenia, and Mood disorders are some of the diseases in associations with CYP2D6, CYP2E1, and CYP3A5 genes (Fig. 8B). Here, CYP2E1 is linked to mood disorder.