CYP2D6 and Parkinson disease: While the Sugiyama model indicated that CYP2D6 had the highest degree of betweenness; both CYP2E1 and CYP3A5 trigger common diseases with CYP2D6. For comprehension purposes it is known that adverse drug reactions (ADRs), Drug Allergy, chemical and drug-induced liver injury, Parkinson’s disease, Schizophrenia, and Mood disorders are some of the diseases in associations with CYP2D6, CYP2E1, and CYP3A5 genes (Fig. 8B).